Rethinking Clinical Trials
نویسندگان
چکیده
منابع مشابه
Rethinking clinical trials: change is coming.
www.sciencemag.org SCIENCE VOL 334 9 DECEMBER 2011 1317 COVER Scanning electron micrograph of a female Anopheles stephensi mosquito, a transmitter of malaria (proboscis length: ~0.6 millimeters). To drive malaria eradication, new medicines that target all stages of the malaria life cycle are needed. In their study, Meister et al. used thousands of A. stephensi mosquitos to identify chemical cla...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
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Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...
متن کاملRethinking composite end points in clinical trials: insights from patients and trialists.
BACKGROUND Many clinical trials use composite end points to reduce sample size, but the relative importance of each individual end point within the composite may differ between patients and researchers. METHODS AND RESULTS We asked 785 cardiovascular patients and 164 clinical trial authors to assign 25 "spending weights" across 5 common adverse events comprising composite end points in cardio...
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The hypothesis that infectious agents are a risk factor for atherosclerosis has implicated multiple viral and bacterial pathogens in contributing either directly or indirectly to disease progression (Rosenfeld and Campbell, 2011). One of the most vigorously studied organisms has been Chlamydia pneumoniae, which has been associated with cardiovascular disease by seroepidemiological studies, dete...
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ژورنال
عنوان ژورنال: Science
سال: 2011
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1212118